Biologics and Nasal Polyposis: A Market Overview



Nasal polyposis causes benign growths in the nasal mucosa that restrict the nasal airway and are a common ailment. They lower quality of life (QoL), the Nasal Polyps symptoms cause hyposmia or anosmia, and impair sleep in people who are affected. They are a prevalent subset of chronic rhinosinusitis that are frequently linked to persistent nasal inflammation and ailments including asthma (CRS). About 25% of those with chronic rhinosinusitis (CRS) who are also diagnosed with nasal polyps have a disease called chronic rhinosinusitis with nasal polyps (CRSwNP), which can be quite debilitating in adulthood.

The Current Nasal Polyposis Treatment Landscape

The main goals of modern nasal polyposis treatment are to reduce polyp growth, postpone surgery, or avoid relapse following surgery. Recurrence rates are both high and common. Nasal corticosteroids are typically the first line of treatment for nasal irritation because the cause is typically unclear. Injectable corticosteroids may be used if the patient doesn't improve.

The US FDA has licenced a number of corticosteroids throughout the years for the treatment of nasal polyposis, including PROPEL (mometasone furoate), SINUVA (mometasone furoate), and XHANCE (fluticasone propionate), however these are not curative, leaving the patients vulnerable. Antihistamines, antibiotics, and NSAIDs may also be given, depending on the patient's needs. Those who are resistant to steroid treatment or who have big polyps may frequently need surgical intervention.


For individuals with cystic fibrosis, the recent approval of biologics as add-on therapy has brought hope. Currently DUPIXENT (dupilumab), NUCALA (mepolizumab), and XOLAIR (omalizumab) are the three biologics licensed for the treatment of nasal polyposis. A strong biologics pipeline for nasal polyposis includes other candidates like FASENRA, CM310, TEZSPIRE (tezepelumab), and Depemokimab (GSK3511294) that are also in development.

Scope of Upcoming Therapies for Nasal Polyposis Treatment

Newer participants in this nasal polyposis therapy market want to follow the success of the current players, who are currently enjoying their victories. Some new nasal polyposis treatments are in the clinical stages of development and are awaiting approval. In the United States, the FDA has approved the use of Fasenra as one such medication for the treatment of nasal polyposis. Although it is too soon to determine if newly developed nasal polyposis medicines like Fasenra and tezepelumab will be profitable, the market adoption of these biologics for nasal polyposis treatment appears to be promising.

Optimistic Future of the Nasal Polyposis Treatment Market

Due to the increasing prevalence of nasal polyposis around the world and the resulting increase in treatment choices, the market for nasal polyposis treatments as a whole is anticipated to grow. In addition to this, the anticipated introduction of cutting-edge medicines will expand the nasal polyposis treatment market.

Also, many pharmaceutical companies are striving to evaluate the difficulties and look for chances that could have an impact on nasal polyposis research and development, leading to a multitude of prospective therapeutics focusing on cutting-edge methods to treat nasal polyps. The global market for treating nasal polyps is anticipated to be significantly affected by the approval of these novel medicines.

On the other hand, incorrect diagnosis of nasal polyposis can be a barrier to the market's expansion for treatment. Moreover, it is difficult to define disease severity using existing techniques. Also, a lack of affordable nasal polyposis treatments, a lack of a strong clinical nasal polyposis pipeline, and a lack of widespread knowledge of nasal polyps may restrain the market's expansion for nasal polyposis treatments in the years to come.


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